Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice an Alzheimer’s disease animal model

摘要

Hippocampal metabolomics of 5xFAD mice at different disease progression stages. Time course of the hippocampal sample collection. Venn diagram representing overlapping ion features that were significantly different between the hippocampi of WT and 5xFAD mice (  c Hierarchically clustered heat map of the relative intensity of 20 metabolic markers. Rows and columns represent the individual mice and the 20 selected metabolites (retention time_m/z, *identified or putative metabolites), respectively. Each cell is colored based on the relative intensity