Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallinaofficinalis L.

摘要

A new cyclic depsipeptide ( ) has been isolated from culture broth of sp. (No. P-100826-4-6) derived from L., together with the known compounds indol-3-carboxylic acid ( ), 1,5-dideoxy-3-C-methyl arabinitol ( ), thymine ( ), uracil ( ), cyclo (L-pro-L-omet) ( ) and macrolactin B ( ). The structure of ( ) was established to be cyclo (2α, 3-diaminopropoinc acid-L-Asn-3-β-hydroxy-5-methyl-tetradecanoic acid-L-Leu -L-Asp-L-Val-L-Leu -L-Leu ) by extensive spectroscopic techniques including H NMR, C NMR, H‒ H COSY, HMBC, HSQC, NOESY, and HRFABMS. The antimicrobial activities of compounds were evaluated. Compounds , and showed moderate antimicrobial activity while compound exhibited a potent antimicrobial and antifungal activities.