It is with great pleasure and enthusiasm that we present to you this Special Issue of Medical Sciences. In this issue, we present a comprehensive and contemporary review of the relationship between chronic rhinosinusitis and other respiratory disorders and, moreover, how our medical and surgical interventions as otolaryngologists impact those respiratory conditions. Our understanding of chronic rhinosinusitis has evolved tremendously over the last two decades. As we have learned, chronic rhinosinusitis—a chronic inflammatory condition of the nasal cavity and paranasal sinuses—is often a local inflammatory response to a systemic or mucosal disorder. The underlying systemic medical conditions not only influence the presentation and diagnosis of chronic rhinosinusitis, but also modify patients’ responses to medical and surgical interventions. Chronic rhinosinusitis associated with cystic fibrosis, for example, is a disorder quite distinct from that associated with aspirin-exacerbated respiratory disease.
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