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Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation

机译：核受体亚家族4组1成员1（Nr4a1）和肝脏亚麻酸酶B1（LKB1）的相互作用通过激活单磷酸激活蛋白激酶（AMPK）/ Sirtuin 1（SIRT1）轴并抑制核因子-κB（2（1） NF-κB）激活

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Yi Ming; Youmin Yin; Zhaoli Sun;
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作者单位

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年(卷),期 2020(26),-1
年度 2020
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
Adipose Tissue; White; Diabetes Mellitus; Type 2; Nuclear Receptor Subfamily 4; Group A; Member 1;

机译：脂肪组织;白色;糖尿病;2型;核受体亚家族4;A组;成员1;

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1. The orphan nuclear receptor NR4A1 promotes Fc epsilon RI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis [J] . Jin Fansi, Li Xian, Deng Yifeng, Allergy . 2019 ,第6期

机译：孤儿核受体NR4A1通过抵消抑制性LKB1 / AMPK轴来促进Fcε1i刺激的肥大酱细胞活化和过敏反应
2. Amiloride inhibits osteoclastogenesis by suppressing nuclear factor-kappa B and mitogen-activated protein kinase activity in receptor activator of nuclear factor-kappa B-induced RAW264.7 cells [J] . Wang Xiangdong, Zhu Yuanli, Zheng Shouchao, Molecular medicine reports . 2015 ,第5期

机译：阿米洛利通过抑制核因子-κB诱导的RAW264.7细胞的受体激活剂中的核因子-κB和有丝分裂原激活的蛋白激酶活性来抑制破骨细胞生成
3. Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Galpha i/o inhibition. [J] . Wu HM, Yang YM, Kim SG Molecular pharmacology. . 2011 ,第5期

机译：Rimonabant是1型大麻素受体反向激动剂，可通过在Galpha I / o抑制下游激活肝激酶B1和AMP激活的蛋白激酶轴来抑制肝细胞脂肪生成。
4. Protein Kinase C Isoform (PKC) Peptide Activator/Inhibitors Exert Cardioprotective Effects in Polymorphonuclear Leukocyte (PMN)-induced Ischemia/Reperfusion (I/R) Injury [C] . Lindon H. Young, Aisha Phillipson, Didi Omiyi American Peptide Symposium . 2006

机译：蛋白激酶C同种型（PKC）肽活化剂/抑制剂在多核白细胞（PMN）中施加心脏保护作用 - 诱导的缺血/再灌注（I / R）损伤
5. Liver Kinase B1 Controls T Follicular Helper Cell Differentiation and Germinal Center Formation through Regulation of Nuclear Factor kappa-light-chain-enhancer of Activated B cells. [D] . Walsh, Nicole Corinne. 2015

机译：肝激酶B1通过调节活化的B细胞的核因子κ轻链增强剂来控制T卵泡辅助细胞的分化和生殖中心的形成。
6. Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy [O] . Vincent Wing Sun Liu, Wing Lung Yau, Chun Wai Tam, 2017

机译：褪黑素抑制前列腺癌细胞中雄激素受体剪接变异体7（AR-V7）诱导的核因子-κB（NF-κB）活化和NF-κB活化剂诱导的AR-V7表达：在体内使用褪黑激素的潜在影响去势抵抗性前列腺癌（CRPC）治疗
7. Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation [O] . Yi Ming, Youmin Yin, Zhaoli Sun 2020

机译：核受体亚家族4组的相互作用4组构件1（NR4A1）和肝共序列B1（LKB1）通过激活单磷酸活性的蛋白激酶（AMPK）/ SIRTUIN 1（SIRT1）轴来缓解2型糖尿病，并抑制核因子-Kappa B（ NF-κB）激活

Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation

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