Drug-induced hypersensitivity syndrome with myocardial involvement treated with tofacitinib

摘要

Summary of clinical course in patient 1. Treatments before and after clinical DIHS flare are listed in the top panel. Doses of prednisone and cyclosporine are shown as milligram per kilogram per day. Doses of tofacitinib are milligrams per day and methotrexate milligrams per week. Methylprednisolone was given at 1 g daily for 3-5 days. Intravenous immunoglobulin (IVIG) was given at 2 g/kg divided over 5 days. Middle panel shows DIHS activity/disease flares ( ), but are not to scale. Lower panel shows the most relevant clinical data during DIHS flares, including ejection fraction (EF) during and after recovery from the flare, when possible. Green highlight signifies an abnormal value. Asterisk signifies every other day. , alanine aminotransferase; , aspartate aminotransferase; , creatine kinase; , central nervous system; , creatinine; , eosinophils; , data not available; , troponin. Additional details for this case can be found in the .