Congenital extraneural hemangioblastoma in alamb

摘要

A 1-mo-old Ivesi male lamb was presented with 2 large red masses on theskin of the left ear. The tumors were removed using gentle dissectionand submitted for histologic evaluation. The tumors consisted ofnumerous thin-walled capillaries lined by endothelial cells and nestsof stromal cells. Immunohistochemically, the endothelial cells werepositive for CD45, and the stromal cells were positive forneuron-specific enolase. GFAP-positive cells were occasionally presentwithin the tumor. Endothelial and stromal cells were negative forS100, CD34, CD31, and factor VIII–related antigen. The tumor hadstrong gross, microscopic, and immunohistochemical similarities withhuman extraneural hemangioblastoma.