首页> 美国卫生研究院文献>Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians Inc >Whole genome sequencing confirms source of pathogens associated withbacterial foodborne illness in pets fed raw pet food
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Whole genome sequencing confirms source of pathogens associated withbacterial foodborne illness in pets fed raw pet food

机译:全基因组测序确认与之相关的病原体来源用生宠物食品喂养的宠物中细菌性食源性疾病

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摘要

Reports of raw meat pet food containing zoonotic foodborne bacteria, including , and , are increasing. Contaminated raw pet food andbiological waste from pets consuming those diets may pose a public health risk.The U.S. Food and Drug Administration Veterinary Laboratory Investigation andResponse Network conducted 2 case investigations, involving 3 households withanimal illnesses, which included medical record review, dietary andenvironmental exposure interviews, animal sample testing, and whole genomesequencing (WGS) of bacteria isolated from the pets and the raw pet food. Foreach case investigation, WGS with core genome multi-locus sequence typinganalysis showed that the animal clinical isolates were closely related to one ormore raw pet food bacterial isolates. WGS and genomic analysis of paired animalclinical and animal food isolates can confirm suspected outbreaks of animalfoodborne illness.
机译:含有人畜共患食源性细菌的生肉宠物食品的报告,包括 和都在增加。受污染的生宠物食品和食用这些饮食的宠物产生的生物废物可能构成公共健康风险。美国食品药品监督管理局兽医实验室调查和响应网络进行了2个案例调查,涉及3个家庭动物疾病,包括病历审查,饮食和环境暴露访谈,动物样本测试和整个基因组从宠物和生宠物食品中分离出的细菌的测序(WGS)。对于每个案例研究,WGS与核心基因组多基因座序列分型分析表明,动物临床分离株与一种或多种密切相关。更多的生宠物食品细菌分离株。 WGS和配对动物的基因组分析临床和动物食品分离株可以确认怀疑是动物暴发食源性疾病。

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