Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE

摘要

Temporal expression of endogenous p-CSF1R, CSF1R, CSF1, p-PLCG2, p-PKCε, and p-CREB in the ipsilateral hemisphere brain after HI. Representative western blot bands of the time course. Western blot data analysis showed that endogenous expression levels of p-CSF1R, CSF1R, CSF1, p-PLCG2, p-PKCε, and p-CREB were upregulated over 7 d after HI, starting at 6 h and peaking at 24 h after HI. < 0.05 vs sham; < 0.05 vs 6 h HI; < 0.05 vs 12 h HI; < 0.05 vs 24 h HI. Data are represented as mean ± SD, = 6 in each group