Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage

摘要

Time course of endogenous CypA in pericyte after subarachnoid hemorrhage. Representative western blot bands and quantitative analysis of CypA from ipsilateral hemisphere after SAH. Representative immunohistochemistry staining slices of CypA (Green), PDGFRβ/CD13 (Red), and Lectin (White) at 24 h after SAH. Representative western blot bands and quantitative analysis of CypA expressions in cultured pericytes after Hb stimulation. Representative immunohistochemistry staining of CypA (Green) in cultured pericytes at 24 h after Hb stimulation. Relative densities of each protein have been normalized against the sham group. = 6 in panel , = 6 in panel ; #: vs. sham < 0.05