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Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers

机译：PI3K和MEK抑制剂的组合在PIK3CA突变的化生性乳腺癌的PDX模型中产生持久缓解

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摘要

Metastasis-free survival (MFS) and overall survival (OS) in 323 different subtypes of TNBC (198 of no special type, 43 apocrine, 36 medullary, 13 metaplastic, and 33 rare TNBCs) analyzed in log-rank tests

机译：在对数秩检验中分析了323种不同的TNBC亚型（无特殊类型的198种，43种顶突，36种髓质，13种化生性和33种稀有TNBC）的无转移生存期（MFS）和总体生存期（OS）。

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期刊名称 Journal of Hematology Oncology
作者
F. Coussy; R. El Botty; M. Lavigne; C. Gu; L. Fuhrmann; A. Briaux; L. de Koning; A. Dahmani; E. Montaudon; L. Morisset; L. Huguet; L. Sourd; P. Painsec; S. Chateau-Joubert; T. Larcher; S. Vacher; S. Melaabi; A. Vincent Salomon; E. Marangoni; I. Bieche;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 10
原文格式 PDF
正文语种
中图分类肿瘤学;血液学检验;
关键词
Metaplastic breast cancer; PI3K inhibitor; MEK inhibitor; Combination of targeted therapies;

机译：化生性乳腺癌;PI3K抑制剂;MEK抑制剂;靶向治疗的组合;

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专利

1. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases [J] . Ni Jing, Ramkissoon Shakti H., Xie Shaozhen, Nature medicine . 2016,第7期

机译：PI3K和mTORC1的组合抑制可在患有原位患者来源的HER2阳性乳腺癌脑转移患者异种移植物的小鼠中产生持久缓解
2. Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer [J] . Jangsoon Lee, Rachael Galloway, Geoff Grandjean, Journal of Cancer . 2015,第12期

机译：全面的二维和三维RNAi筛选可确定PI3K抑制是MEK抑制剂AS703026的补充，用于三阴性乳腺癌的联合治疗。
3. PI3K inhibitor provides durable response in metastatic metaplastic carcinoma of the breast: A hidden gem in the BELLE-4 study [J] . Ming-Han Yang, I-Chun Chen, Yen-Shen Lu Journal of the Formosan Medical Association =: Taiwan yi zhi . 2019,第9期

机译：PI3K抑制剂可在乳腺转移性化生癌中提供持久的响应：BELLE-4研究中的一个隐藏的宝石
4. QSAR modeling and structure based virtual screening of new PI3K/mTOR inhibitors as potential anticancer agents [C] . Jelena Oluic, Katarina Nikolic, Mica Vucicevic International Conference on Medical and Biological Engineering . 2017

机译：基于QSAR建模和基于结构的新PI3K / MTOR抑制剂的虚拟筛选潜在抗癌剂
5. Targeting the MEK5, MEK1/2, and/or Pi3k Pathways Reverses Epithelial to Mesenchymal Transition and Enhances Chemotherapeutic Sensitivity in Breast and Brain Cancers with a Mesenchymal Phenotype [D] . Bhatt, Akshita B. 2021

机译：靶向MEK5，MEK1 / 2和/或PI3K途径将上皮细胞转型的上皮性反转，并通过间充质表型提高乳腺癌和脑癌中的化疗敏感性
6. Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases [O] . Jing Ni, Shakti H. Ramkissoon, Shaozhen Xie, -1

机译：PI3K和mTORC1的联合抑制可在原位患者来源的HER2阳性乳腺癌脑转移患者异种移植物中产生持久缓解
7. Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer [O] . Jangsoon Lee, Rachael Galloway, Geoff Grandjean, 2015

机译：综合的两维和三维RNAi筛选将PI3K抑制抑制为MEK抑制剂AS703026的补充，用于组合治疗三重阴性乳腺癌

Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers

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