Up-regulated LINC01234 promotes non-small-cell lung cancer cell metastasis by activating VAV3 and repressing BTG2 expression

摘要

LINC01234 is overexpressed in NSCLC and its clinical significance. Data mining of altered lncRNA expression in TCGA NSCLC sequencing data (LUAD and LUSC). Data mining of correlation between LINC01234 expression and lung adenocarcinoma stage in TCGA dataset. qRT-PCR analysis of LINC01234 expression in 45 pairs of NSCLC tissues and adjacent non-tumor lung tissues. qRT-PCR analysis of LINC01234 expression in 16HBE cells and five NSCLC cell lines. Forty-five NSCLC tumor tissues were divided into two groups (high and low LINC01234 expression) based on the median value. , Relationship between LINC01234 expression and clinicopathological features of patients with NSCLC. Kaplan–Meier survival plots of OS based on LINC01234 expression in lung cancer patients (  = 1928). *  P