Molecular Characterization of a Catalase-Negative Staphylococcus aureus subsp. aureus Strain Collected from a Patient with Mitral Valve Endocarditis and Pericarditis Revealed a Novel Nonsense Mutation in the katA Gene

摘要

We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis.