Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells

摘要

Aβ treatment suppressed cell viability and induced apoptosis in SH-SY5Y cells. SH-SY5Y cells were exposed to different concentrations (0, 5, 10, 25, 50 μM) of Aβ for 48 h. MTT assay was conducted to determine the viability. ELISA assay was performed to detect the caspase3 protein level. Flow cytometry analysis was applied to determine apoptotic rate.