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Design Construction and Immunogenicity Assessment of pEGFP-N1-KMP11-GP96 (Fusion) as a DNA Vaccine Candidate against Leishmania major Infection in BALB/c Mice

机译：pEGFP-N1-KMP11-GP96（融合）作为抗BALB / c小鼠利什曼原虫主要感染的DNA疫苗的设计构建和免疫原性评估

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KMP-11 (Kinetoplastid membrane protein-Π) exists in all species of kinetoplastid family. It is fully conserved and the protein produced by this gene can induce a very high cellular immune response. We aimed to design a suitable construction for a DNA vaccine and evaluate the protective efficacy of it as a candidate for DNA vaccine against cutaneous leishmaniasis in BALB/c mice.

机译：KMP-11（动质体膜蛋白-II）存在于动质体家族的所有物种中。它是完全保守的，该基因产生的蛋白质可以诱导很高的细胞免疫应答。我们旨在设计一种适合DNA疫苗的构建体，并评估其作为抗BALB / c小鼠皮肤利什曼病的DNA疫苗候选物的保护效果。

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期刊名称 Iranian Journal of Parasitology
作者
Abdolhossein DALIMI; Vahid NASIRI;
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作者单位

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年(卷),期 2020(15),1
年度 2020
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学;医学寄生虫学;
关键词
Fusion gene; Vaccine;

机译：融合基因;疫苗;

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专利

1. Design, Construction and Immunogenicity Assessment of pEGFP-N1-KMP11-GP96 (Fusion) as a DNA Vaccine Candidate against Leishmania major Infection in BALB/c Mice [J] . DALIMI ABDOLHOSSEIN, NASIRI VAHID Iranian Journal of Parasitology. . 2020,第1期

机译：PEGFP-N1-KMP11-GP96（融合）的设计，施工和免疫原性评估作为BALB / C小鼠对Leishmania主要感染的DNA疫苗候选者
2. Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice [J] . Manuel Soto, Laura Corvo, Esther Garde, PLOS Neglected Tropical Diseases . 2015,第5期

机译：三种抗原性婴儿利什曼原虫Poly（A）结合蛋白作为DNA疫苗的共同给药诱导针对BALB / c小鼠的利什曼原虫主要感染的保护作用。
3. The Leishmania infantum Acidic Ribosomal Protein P0 Administered as a DNA Vaccine Confers Protective Immunity to Leishmania major Infection in BALB/c Mice [J] . Salvador Iborra, Manuel Soto, Javier Carrión, Infection and immunity . 2003,第11期

机译：婴儿利什曼原虫酸性核糖体蛋白P0作为DNA疫苗给予BALB / c小鼠利什曼原虫主要感染的保护性免疫
4. Assessment of Profile of Antigenicity and Immunogenicity of Eimeria maxima and Eimeria tenella through Propagative Level and Histopathological Changes in Site Infection for Exploration of Optimal Low Doses of Bivalent Chicken Coccidiosis Live Vaccine [C] . Endang Suprihati, Muchammad Yunus International Conference in One Health . 2018

机译：通过繁殖水平和育龄病理学变化评估eimeria maxima和eimeria tenella的抗原性和免疫原性的概况，以探讨最佳低剂量的二价鸡椰子病活疫苗
5. Evaluation of protection induced by DNA vaccine candidate against Leishmania mexicana in BALB/c mice model. [D] . Rodarte, Rosina. 2012

机译：在BALB / c小鼠模型中评估DNA候选疫苗诱导的针对墨西哥利什曼原虫的保护作用。
6. Construction of a Novel DNA Vaccine Candidate encoding LmSTI1-PpSP42 Fusion Protein from Leishmania major and Phlebotomus papatasi Against Cutaneous Leishmaniasi [O] . Touraj Miandoabi, Fariborz Bahrami, Vahideh Moein Vaziri, 2018

机译：利什曼原虫和巴氏疟原虫对皮肤利什曼原虫的编码LmSTI1-PpSP42融合蛋白的新型DNA候选疫苗的构建
7. Effect of interleukin-22 on immunogenicity of DNA vaccine encoding TSA gene of leishmania major in BALB/c mice [O] . Ziaei-Hezarjaribi H., Ghaffarifar F., Dalimi-Asl A., 2014

机译：白介素-22对BALB / c小鼠大利什曼原虫TSA基因编码DNA疫苗免疫原性的影响
8. Shigella sonnei Vaccine Candidates WRSs2 and WRSs3 Are as Immunogenic as WRSS1, a Clinically Tested Vaccine Candidate, in a Primate Model of Infection [R] . Barnoy, S., Baqar, S., Kaminski, R. W., 2011

机译：志贺氏志贺菌疫苗候选物WRss2和WRss3与感染灵长类动物模型中的临床试验疫苗候选物WRss1一样具有免疫原性。

Design Construction and Immunogenicity Assessment of pEGFP-N1-KMP11-GP96 (Fusion) as a DNA Vaccine Candidate against Leishmania major Infection in BALB/c Mice

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