The efficacy of 99mTc-MIBI imaging in 125I seed implantation treatment of rabbit VX2 transplanted liver cancer

摘要

Purpose: To evaluate the efficacy of Tc-MIBI imaging in the evaluation of I radioactive particle implantation for treatment of rabbit VX2 transplanted liver cancer. Methods: Twelve New Zealand white rabbit VX2 liver cancer models were successfully prepared by tumor cell suspension method and randomly divided into a control group and treatment group. The treatment group received I particle implantation according to the TPS plan, and the control group received the same number of hollow particle implantation. Tc-MIBI imaging was performed before and 7 d, 14 d, and 28 d after implantation. The target lesion (target, T) and normal liver tissue (nontarget, N) were determined by region of interest (ROI) technique. Radioactivity count was used to calculate the Tc-MIBI uptake ratio (target-to-nontarget ratio, T/N) between the target lesion and normal liver tissue, thereby obtaining early ratio (ER) and delayed ratio (DR), respectively. The retention index (RI) was calculated. The mice were sacrificed after 28 days for histopathologic observation. Results: The T/N ratio, ER, and DR showed no statistical changes following the implantation time in the control group. In the treatment group, ER and DR gradually decreased after implantation of I seeds (P < 0.05). There was no significant difference in RI during different observation times between the treatment group and the control group. Compared with the treatment group, RI exhibited no statistical difference between before and 7 d, 7~14 d, and 14~28 d after implantation (P > 0.05). Conclusion: This method has value in evaluating the efficacy of I seed implantation treatment of rabbit VX2 transplanted liver cancer. The T/N ratio is independent of the tumor diameter, but is related to the blood perfusion and metabolic state of the tumor. Implantation of I particles into the rabbit transplanted liver cancer can effectively inhibit tumor growth, thus is a safe and effective method.