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首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Pathology >Detection of immunoglobulin and T-cell receptor gene rearrangements in angioimmunoblastic T-cell lymphoma
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Detection of immunoglobulin and T-cell receptor gene rearrangements in angioimmunoblastic T-cell lymphoma

机译：血管免疫母细胞性T细胞淋巴瘤中免疫球蛋白和T细胞受体基因重排的检测

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To assess the value of immunoglobulin and T-cell receptor gene rearrangements in the diagnosis and differential diagnosis of angioimmunoblastic T-cell lymphoma. We selected 55 cases of angioimmunoblastic T-cell lymphoma confirmed by histopathology and 15 cases of reactive lymph node hyperplasia. Using the IdentiClone gene rearrangement detection kit, BIOMED-2 primer system, and GeneScanning analysis, we tested for immunoglobulin and T-cell receptor gene rearrangements. Among all 55 angioimmunoblastic T-cell lymphoma cases, 1 (2%) displayed the first type of angioimmunoblastic T-cell lymphoma, which has an intact lymphoid follicle structure. Five cases (9%) displayed the second type, which has an intact segmental lymphatic follicular structure. Forty-nine cases (89%) displayed the third type, which is characterized by a complete obliteration of the lymphatic follicular structure. Fifty-two cases (95%) had tumor cells that were positive for CD3, 50 cases (91%) were positive for CD4, 33 cases (60%) were positive for Bcl-6, 20 cases (36%) were positive for CD10, 44 cases (80%) were positive for CXCL13 to different degrees, and 53 cases (96%) showed a strong positive expression of CD21. Ki67 expression intensity was 30-80% in tumor T cells. Clonal gene rearrangements were identified in 48 of the 55 angioimmunoblastic T-cell lymphoma cases (87%), of which 30 (55%) displayed IG gene rearrangements, including IGHA (7 cases; 13%), IGHB (6 cases; 11%), IGHC (2 cases; 4%), IGKA (22 cases; 40%), IGKB (6 cases; 11%), and IGL (20 cases; 36%). TCR gene rearrangements were observed in 32 cases (58%), including TCRBA (6 cases; 11%), TCRBB (5 cases; 9%), TCRBC (10 cases; 18%), TCRD (7 cases; 13%), TCRGA (22 cases; 40%), and TCRGB (16 cases; 29%). IG and TCR gene rearrangements were concurrently observed in 14 cases (25%). Immunoglobulin or TCR clonal gene rearrangements were not detected in the 15 cases of reactive hyperplasia. Angioimmunoblastic T-cell lymphomas may be positive for immunoglobulin or T-cell receptor clone gene rearrangements or may express double rearrangements. The assessment of clonal gene rearrangements is valuable for the diagnosis and differential diagnosis of angioimmunoblastic T-cell lymphoma.
机译：评估免疫球蛋白和T细胞受体基因重排在诊断和鉴别诊断血管免疫母细胞性T细胞淋巴瘤中的价值。我们选择了55例经组织病理学证实的血管免疫母细胞性T细胞淋巴瘤和15例反应性淋巴结增生。使用IdentiClone基因重排检测试剂盒，BIOMED-2引物系统和GeneScanning分析，我们测试了免疫球蛋白和T细胞受体基因重排。在55例血管免疫母细胞性T细胞淋巴瘤病例中，有1例（2％）显示出第一类血管免疫母细胞性T细胞淋巴瘤，其淋巴滤泡结构完整。五例（9％）显示出第二种类型，其具有完整的节段性淋巴滤泡结构。 49例（89％）显示出第三种类型，其特征是淋巴滤泡结构完全消失。 52例（95％）的肿瘤细胞CD3阳性，50例（91％）的CD4阳性，33例（60％）的Bcl-6阳性，20例（36％）的CD3阳性。 CD10中，有44例（80％）的CXCL13呈阳性，而53例（96％）的CD21呈强阳性表达。在肿瘤T细胞中，Ki67表达强度为30-80％。 55例血管免疫母细胞性T细胞淋巴瘤病例中有48例发生克隆基因重排（87％），其中30例（55％）显示IG基因重排，包括IGHA（7例; 13％），IGHB（6例; 11％） ），IGHC（2例; 4％），IGKA（22例; 40％），IGKB（6例; 11％）和IGL（20例; 36％）。观察到TCR基因重排32例（58％），包括TCRBA（6例; 11％），TCRBB（5例; 9％），TCRBC（10例; 18％），TCRD（7例; 13％）， TCRGA（22例； 40％）和TCRGB（16例； 29％）。同时观察到IG和TCR基因重排14例（25％）。在15例反应性增生中未检测到免疫球蛋白或TCR克隆基因重排。血管免疫母细胞性T细胞淋巴瘤可能对免疫球蛋白或T细胞受体克隆基因重排呈阳性，或可能表达双重重排。克隆基因重排的评估对于血管免疫母细胞性T细胞淋巴瘤的诊断和鉴别诊断是有价值的。

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