Dual Effect of IL-6 -174 G/C Polymorphism and Promoter Methylation in the Risk of Coronary Artery Disease Among South Indians

摘要

The IL-6 gene, located at chromosome 7p21–24 is composed of 4 introns and 5 exons. Polymorphic variants in the IL-6 gene promoter may affect the expression and secretion of IL-6 and subsequently altered circulating levels might result in relevant biological responses, that leads to the pathogenesis of various diseases such as CAD, myocardial infarction (MI) and ischemic stroke [ ]. Polymorphisms in the promoter region (G-597A, G-572C, G-174C) of IL-6 gene have been well studied [ – ], among which, the single nucleotide change from G to C at position -174 (rs1800795) is a crucial polymorphism that affects IL-6 production, therefore predispose an individual to cardiovascular events [ , ]. Several studies have reported that IL-6 -174 polymorphism has been associated with CAD [ , ], type II diabetes mellitus [ ]. In a meta-analysis, reported the significant association between the incidence of stroke and IL- -174G/C polymorphism [ , ].