Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster

摘要

Experimental design and mating scheme to produce and maintain full-sib inbred lines and an outbred control during five (Experiment I) or six (Experiment II) generations, and their corresponding inbreeding coefficient ( ) reached. : total number of inbred lines (50 for Exp I and 68 for Exp II. nb: Number of bottles of Base Population (30 for Exp I and 50 for Exp II). The control line is maintained with maximum avoidance of inbreeding