Disruption of KCNQ1 prevents methylation of the ICR2 and supports the hypothesis that its transcription is necessary for imprint establishment

摘要

Overview of the imprinted domains on chromosome 11p15.5. Given are the two imprinting control regions (ICRs) on chromosome 11p15.5. The centromeric :TSS-DMR is methylated on the maternal allele (grey square). It regulates the expression of the maternally expressed genes and (depicted in red) and the paternally expressed (blue). The biallelically expressed gene is shown in black. The telomeric :IG-DMR is methylated on the paternal allele with the maternally expressed and the paternally expressed gene. telomeric, centromeric. Modified from Beygo et al. 2016