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Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo‐controlled trial

机译：口服改良释放吗啡用于慢性心力衰竭的呼吸困难：一项随机安慰剂对照试验

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摘要

Morphine is shown to relieve chronic breathlessness in chronic obstructive pulmonary disease. There are no definitive data in people with heart failure. We aimed to determine the effectiveness and cost‐effectiveness of 12 weeks morphine therapy for the relief of chronic breathlessness in people with chronic heart failure compared with placebo.

机译：经证明，吗啡可缓解慢性阻塞性肺疾病中的慢性呼吸困难。心力衰竭患者没有确切的数据。我们旨在确定与安慰剂相比，为期12周的吗啡疗法对缓解慢性心力衰竭患者的慢性呼吸困难的有效性和成本效益。

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期刊名称 ESC Heart Failure
作者
Miriam J. Johnson; Sarah Cockayne; David C. Currow; Kerry Bell; Kate Hicks; Caroline Fairhurst; Rhian Gabe; David Torgerson; Laura Jefferson; Stephen Oxberry; Justin Ghosh; Karen J. Hogg; Jeremy Murphy; Victoria Allgar; John G.F. Cleland; Andrew L. Clark;
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作者单位

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年(卷),期 2019(6),6
年度 2019
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Heart failure; Randomized controlled trial; Morphine; Breathlessness; Dyspnoea;

机译：心力衰竭;随机对照试验;吗啡;呼吸困难;呼吸困难;

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专利

1. A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study proto [J] . Miriam Johnson, Andrew A Somogyi, Katherine C Clark, BMJ Open . 2017,第7期

机译：实用，III期，多部位，双盲，安慰剂对照，平行臂，剂量递增的随机，低剂量吗啡缓释吗啡治疗慢性呼吸困难的随机试验：呼吸困难，运动和硫酸吗啡（BEAMS）研究原型
2. Regular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial (vol 75, pg 50, 2020) [J] . Thorax: The Journal of the British Thoracic Society . 2020,第7期

机译：常规，持续释放的吗啡用于慢性呼吸：多期，双盲，随机，安慰剂对照试验（Vol 75，PG 50,2020）
3. Regular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial [J] . Currow David, Louw Sandra, McCloud Philip, Thorax: The Journal of the British Thoracic Society . 2020,第1期

机译：常规，持续释放的吗啡用于慢性呼吸困难：多方形，双盲，随机，安慰剂对照试验
4. MULTI-CENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED STUDY OF ORAL TOCERANIB PHOSPHATE (PALLADIATM, SU11654), A RECEPTOR TYROSINE KINASE INHIBITOR, FOR THE TREATMENT OF DOGS WITH RECURRENT MAS [C] . Cheryl L London, Carolyn J Henry, Anthony W Rusk, Annual conference of the Veterinary Cancer Society . 2008

机译：多中心，安慰剂对照，双盲，随机研究口服Toceranib磷酸盐（Palladia TM，SU11654），受体酪氨酸激酶抑制剂，用于治疗经常性MAS的狗
5. A randomized, double-blind, placebo-controlled, clinical trial of curcuminoids in oral lichen planus. [D] . Wu, Nita Chainani. 2005

机译：口服扁平苔藓中姜黄素类药物的随机，双盲，安慰剂对照临床试验。
6. A pragmatic phase III multisite double-blind placebo-controlled parallel-arm dose increment randomised trial of regular low-dose extended-release morphine for chronic breathlessness: Breathlessness Exertion And Morphine Sulfate (BEAMS) study protocol [O] . David Currow, Gareth John Watts, Miriam Johnson, 2017

机译：实用III期多部位双盲安慰剂对照平行臂剂量递增的随机低剂量吗啡用于慢性呼吸困难的随机试验：呼吸困难运动和硫酸吗啡（BEAMS）研究方案
7. A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-Arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness : Breathlessness, Exertion and Morphine Sulfate (BEAMS) study protocol [O] . Currow, David, Watts, Gareth John, Johnson, Miriam, 2017

机译：一项实用的，III期，多部位，双盲，安慰剂对照，平行臂，剂量增量随机试验，定期，低剂量缓释吗啡用于慢性呼吸困难：呼吸困难，运动和硫酸吗啡（BEams）研究方案

Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo‐controlled trial

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