SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors

摘要

Somatostatin receptor type 5 (SST5) is inconsistently expressed by corticotroph tumors, with higher expression found in corticotropinomas having ubiquitin-specific protease 8 ( ) mutations. Aims were to study the correlation between characteristics of corticotropinomas and SST5 expression/ mutation status and to describe the response to pasireotide in five patients.