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Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model

机译：依达拉奉通过下调大鼠复苏模型中的内质网应激缓解肾脏热缺血再灌注损伤。

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摘要

This study was conducted to explore whether the effect of edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol3-one, EDR) can ameliorate renal warm ischemia-reperfusion injury (IRI) by modulating endoplasmic reticulum stress (ERS) and its downstream effector after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a rat model.

机译：进行这项研究的目的是探讨依达拉奉（5-甲基-2-苯基-2,4-二氢-3H-吡唑-3-酮，EDR）的作用是否可以通过调节内质网应激来减轻肾温暖性缺血-再灌注损伤（IRI）（ERS）及其在心脏骤停（CA）和心肺复苏（CPR）后的下游效应子。

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期刊名称 Drug Design Development and Therapy
作者
Zhao-Yin Fu; Zhi-Jiang Wu; Jun-Hui Zheng; Nuo Li; Jun-Yu Lu; Meng-Hua Chen;
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作者单位

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年(卷),期 2020(14),-1
年度 2020
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
renal warm ischemia-reperfusion injury; edaravone; endoplasmic reticulum stress; cardiac arrest; cardiopulmonary resuscitation;

机译：肾温暖缺血再灌注损伤;依达拉奉;内质网应激;心脏骤停;心肺复苏;

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专利

1. Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model [J] . Zhao-Yin Fu, Zhi-Jiang Wu, Jun-Hui Zheng, Drug Design, Development and Therapy . 2020,第1期

机译：埃及龙酮通过下调大鼠复苏模型中的内质网胁迫来改善肾温缺血再灌注损伤
2. Ameliorative effect of sevoflurane on endoplasmic reticulum stress mediates cardioprotection against ischemia-reperfusion injury [J] . Liu Ai-Jie, Pang Chun-Xia, Liu Guo-Qiang, Canadian Journal of Physiology and Pharmacology . 2019,第5期

机译：七氟醚对成内质网胁迫的改善作用介导心脏保护反应缺血再灌注损伤
3. Hydrogen-Rich Saline Ameliorates Hepatic Ischemia-Reperfusion Injury Through Regulation of Endoplasmic Reticulum Stress and Apoptosis [J] . Zhiyuan Lu, Yanzhu Lin, Bo Peng, Digestive Diseases and Sciences . 2017,第12期

机译：通过调节内质网胁迫和凋亡来改善富含氢气的盐水改善肝缺血再灌注损伤
4. Effects of Radix Total Glucosides of Paeonia on the Endoplasmic Reticulum Stress and Macrophage Recruitment on Diabetic Cardiomyopathy Rats [C] . Hongyu Kang, Ximin Liu, Yaping Zheng, International Conference on Materials Engineering and Information Technology Applications . 2017

机译：芍药的含量对糖尿病心肌病大鼠内质网胁迫和巨噬细胞募集的影响
5. Potential role of endoplasmic reticulum redox changes in endoplasmic reticulum stress and impaired protein folding in obesity-associated insulin resistance [D] . Sarkar, Deboleena 2013

机译：内质网氧化还原变化在内质网应激和蛋白质折叠受损在肥胖相关胰岛素抵抗中的潜在作用
6. Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury [O] . Bhavya B. Chandrika, Cheng Yang, Yang Ou, -1

机译：内质网应激诱导的自噬提供细胞对化学性缺氧和氧化剂损伤的保护作用并减轻肾缺血-再灌注损伤。
7. Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury. [O] . Bhavya B Chandrika, Cheng Yang, Yang Ou, 2015

机译：内质网应激诱导的自噬提供化学缺氧和氧化损伤的细胞保护和改善肾缺血再灌注损伤。

Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model

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