Application of the Frameworks of Intrinsic Capacity and the Hallmarks of Aging to Validate Nicotinamide Riboside as a Healthy Aging Supplement – A Meta-Analysis

摘要

Introduction: Demonstrating the benefits of nutritional supplements on healthy aging has been challenging, as research has tended to focus on affecting disease rather than health optimization. We propose that by applying the frameworks of intrinsic capacity and the hallmarks of aging, one can more definitively demonstrate measurable benefits of a nutritional supplement. To test the validity of this approach, research previously and actively being conducted on nicotinamide riboside (NR), a precursor to the essential coenzyme nicotinamide adenine dinucleotide (NAD) was evaluated. NAD levels have been shown to decrease with age, thus NR is widely promoted as a nutritional solution for healthy aging. Objective: The goal of this analysis was to determine if the combined frameworks of intrinsic capacity and the hallmarks of aging can be used to demonstrate the benefits of NR supplementation.