Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains

摘要

VAR2CSA sequences from the maternal isolate M200101 and NF54 at different weeks of in vitro culture were analyzed and assembled using the consensus protein pileups tool. End of DBL6ɛ domain of VAR2CSA for both isolates is indicated in the purple box, and the transmembrane domain (TMD) motif for NF54 is highlighted in green. The beginning and end of the DBL7ɛ domain of M200101 sequences are shown in the blue boxes. Using the TMHMM Server, v. 2.0 the predicted TMD for M200101 is indicated in the red box.