Irradiation induces p53 loss of heterozygosity in breast cancer expressing mutant p53

摘要

The survival of mutp53 breast cancer patients following radiotherapy is stage-dependent. Kaplan-Meier survival curve for patients (  = 2433) with breast cancer receiving radiation therapy (red line) or untreated (blue line). All breast cancer patients (  = 0.00079). Patients with TP53 and ErbB2 mutations (  = 193,  = 0.033). Stage 1, all breast cancer patients (  = 440,  = 0.98). Stage 2, all breast cancer patients (  = 759,  = 0.00026). Stage 1 patients with TP53 and ErbB2 mutations (  = 35,  = 0.049). Stage 2 patients with TP53 and ErbB2 mutations (  = 70,  = 0.0019). Stage 1 patients with wild-type p53 (  = 302,  = 0.26). Stage 2 patients with wild-type p53 (  = 458,  = 0.017). TP53 LOH in breast cancer patients is stage-dependent. 52% of stage I and only 20% stage II mutp53 tumors retain wtp53 allele.