Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction

摘要

Significantly different transcriptome of FGR and control umbilical cord blood. – Hierarchical clustering analysis identified 339 protein coding genes ( ), 295 lncRNAs ( ), and 13 miRNAs ( ), that are differentially expressed between FGR and the corresponding control. Examples of critical protein coding genes (S100A6, S100A4) expressed in normal control that is repressed in FGR. Examples of critical lncRNAs (LINC01291, LINC01293) not expressed in normal control that becomes activated in FGR