Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma

摘要

Genome-wide DNA methylation of low-grade adenoma (LGA), high-grade colorectal adenoma (HGA), and normal colorectal tissue. t-SNE analysis highlights the data structure and sample relationship among the sample groups. PCA analysis confirms the data structure and sample relationship of the t-SNE analysis. Average methylation levels of normal (N), LGA, and HGA samples. Density plot reveals the distribution of the whole array probes for N, LGA, and HGA samples. Number of sites in ranging from 0.7 to 0.9. Heatmap of the 209 hyper-methylated DMSs of in-house datasets and samples from 504 public cancer datasets. DMR between LGA and normal tissues, HGA and normal tissue, and HGA and LGA. Venn graph highlights the relationships among all DMRs