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Genetic variants of rs1275988 and rs2586886 in TWIK-related acid-sensitive K+ channel-1 gene may be potential risk factors for obese patients with obstructive sleep apnea

机译：TWIK相关酸敏感的K +通道1基因中rs1275988和rs2586886的遗传变异可能是肥胖阻塞性睡眠呼吸暂停患者的潜在危险因素

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摘要

The pathogenesis of obstructive sleep apnea (OSA) remains not fully understood. This study aimed to explore the mechanism of OSA by assessing the association between the human tandem of P domains in a weak inwardly rectifying K channel (TWIK)-related acid-sensitive K channel-1 ( ) gene and OSA.

机译：阻塞性睡眠呼吸暂停（OSA）的发病机制仍未完全了解。本研究旨在通过评估弱内向整流K通道（TWIK）相关酸敏感性K通道1（）基因中P结构域的人串联结构来探索OSA的机制。

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期刊名称 Chinese Medical Journal
作者
Tian Shi; Xiao-Guang Yao; Mei Li; Mulalibieke Heizhati; Xiu-Fang Li; Lu Wen; Yuan-Yuan He; Ling Yao; Ying-Chun Wang; Jing Hong; Nan-Fang Li;
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作者单位

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年(卷),期 2019(132),17
年度 2019
页码 -1
总页数 7
原文格式 PDF
正文语种
中图分类基础医学;
关键词
Potassium channels; Obstructive sleep apnea; Single nucleotide polymorphism; Body mass index;

机译：钾通道;阻塞性睡眠呼吸暂停;单核苷酸多态性;身体质量指数;

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专利

1. Genetic variants of rs1275988 and rs2586886 in TWIK-related acid-sensitive K+ channel-1 gene may be potential risk factors for obese patients with obstructive sleep apnea [J] . Tian Shi, Jing Hong, Nan-Fang Li, 中华医学杂志（英文版） . 2019,第017期

机译：TWIK相关酸敏感的K +通道1基因中rs1275988和rs2586886的遗传变异可能是肥胖阻塞性睡眠呼吸暂停患者的潜在危险因素
2. GW29-e0816 The genetic polymorphisms of TWIK-related acid-sensitive K+ channel-3 (TASK-3) were associated with obstructive sleep apnea in patients with hypertension [J] . Lu Wen, Xiaoguang Yao, Nanfang Li Journal of the American College of Cardiology . 2018,第16期

机译：GW29-E0816 TWIK相关酸敏感K +通道-3（任务-3）的遗传多态性与高血压患者的阻塞性睡眠呼吸暂停相关
3. GW29-e0814 Genetic polymorphisms of pulmonary surfactant-associated protein A gene may be potential risk factors of severe obstructive sleep apnea [J] . Ling Yao, Xiaoguang Yao, Nanfang Li Journal of the American College of Cardiology . 2018,第16期

机译：GW29-E0814肺表面活性剂相关蛋白A基因的遗传多态性可能是严重阻塞性睡眠呼吸暂停的潜在危险因素
4. Study of the Obstructive Sleep Apnea in the Patients with Cardiovascular Risk [C] . Hoang Anh Tien, Nguyen Huu Duc International Conference on the Development of Biomedical Engineering in Vietnam . 2020

机译：心血管风险患者阻塞性睡眠呼吸暂停研究
5. Sleep/wake activity and energy expenditure in overweight and obese obstructive sleep apnea patients: A pre- and post-CPAP comparison [D] . McCullough, Pamela A. 2011

机译：超重和肥胖阻塞性睡眠呼吸暂停患者的睡眠/唤醒活动和能量支出：CPAP后和后后比较
6. Genetically-reduced serum ACE activity might be a causal risk factor for obstructive sleep apnea syndrome: A meta-analysis [O] . Lan He, Bin Wang, Wei-Ya Lang, -1

机译：基因降低的血清ACE活性可能是阻塞性睡眠呼吸暂停综合征的致病危险因素：一项荟萃分析
7. Genetic variants of rs1275988 and rs2586886 in TWIK-related acid-sensitive K+ channel-1 gene may be potential risk factors for obese patients with obstructive sleep apnea [O] . Tian Shi, Xiao-Guang Yao, Mei Li, 2019

机译：TWIK相关酸敏感k +通道-1基因的遗传变异为RS1275988和RS2586886，可能是肥急睡眠呼吸暂停患者的潜在危险因素

Genetic variants of rs1275988 and rs2586886 in TWIK-related acid-sensitive K+ channel-1 gene may be potential risk factors for obese patients with obstructive sleep apnea

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