CaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts

摘要

Representative heart slice TTC staining. Scale bar, 0.5 cm. , Grouped results of myocardial injury area and LDH release in the coronary effluent, respectively. Grouped results of caspase-3 activity. Representative blots of cytochrome c in mitochondrial and cytosolic fraction and grouped results of densitometric analysis. GAPDH and COX IV served as a loading controls. The values are expressed as the percentages of the control values. Each bar represents the mean ± SEM;  = 6 rats in each group. Western blots were performed in five independent biological experiments and for three technical replicates per sample. **  2+ paradox, KBR KB-R7943, MIA myocardial injury area, Ry ryanodine, Th Thapsigargin.