Unique case of ANCA-negative pauci-immune necrotizing glomerulonephritis with diffuse alveolar hemorrhage potentially associated with midostaurin

摘要

Acute tubular epithelial injury consistent with acute tubular necrosis (ATN) and mild arterial and arteriolar sclerosis. Red blood cell casts (right). Bar = 50 µm. Crescent composed primarily of fibrin with early epithelial proliferation indicating very acute necrotizing glomerulonephritis. Bar = 20 µm. Jones Silver stain: very segmentally interrupted Glomerular Basement Membrane (GBM arrow). IgA trace mesangial deposits. IgG negative glomerulus. Electron microscopy with normal structure and no deposits