LINC00689 promotes prostate cancer progression via regulating miR-496/CTNNB1 to activate Wnt pathway

摘要

LINC00689 is upregulated in prostate cancer tissues and cells. The expression of LINC00689 in adjacent-normal (n = 80) and tumor (n = 80) tissues was detected by RT-qPCR. The expression of LINC00689 in normal prostate epithelial cell (RWPE1) and PCa cells (DU145, LNCaP, PC-3 and C42B) were detected by RT-qPCR. Relative LINC00689 expression in different clinical stages (early I/II and advanced III/IV) was measured by RT-qPCR. Kaplan–Meier curve and the log-rank test showed that the correlation between high or low LINC00689 expression and overall survival in patients with PCa. Error bars represent the mean ± SD of at least three independent experiments. P