Pharmacokinetics and pharmacodynamics of ropinirole in patients with prolactinomas

机译：罗匹尼洛在泌乳素瘤患者中的药代动力学和药效学

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摘要

Treatment of prolactinomas with ergoline dopamine agonists can be complicated by intolerance and resistance. This study investigated the pharmacokinetics and pharmacodynamics of the nonergot dopamine agonist ropinirole, to assess its therapeutic potential as a novel therapy for prolactinomas.

机译：用麦角灵多巴胺激动剂治疗泌乳素瘤会因不耐受和耐药而变得复杂。这项研究调查了非麦角多巴胺激动剂罗匹尼罗的药代动力学和药效学，以评估其作为催乳素瘤新疗法的治疗潜力。

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期刊名称 British Journal of Clinical Pharmacology
作者
Sihang Liu; Can Hu; Jane Peters; Amanda Tsang; Serge Cremers; Robert Bies; Gabrielle Page‐Wilson;
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作者单位

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年(卷),期 2019(85),2
年度 2019
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
modelling and simulation; pharmacokinetic–pharmacodynamic; pharmacometrics; ropinirole; therapeutics;

机译：建模与仿真;药代动力学–药效学;药理学;罗替尼罗;治疗药物;

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专利

1. Pharmacokinetics and pharmacodynamics of ropinirole in patients with prolactinomas [J] . Liu Sihang, Hu Can, Peters Jane, British Journal of Clinical Pharmacology . 2019,第2期

机译：丙氨酸患者Ropinirole的药代动力学和药效学
2. Pharmacokinetic and pharmacodynamic comparison of ropinirole 24-hour prolonged release and ropinirole immediate release in patients with Parkinson's disease. [J] . Tompson D, Oliver Willwong R Clinical neuropharmacology . 2009,第3期

机译：帕金森氏病患者中罗匹尼罗24小时延长释放和罗匹尼罗立即释放的药代动力学和药效学比较。
3. Predicting the dopamine D-2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic-pharmacodynamic modeling [J] . Huang Chenrong, Wang Ziteng, Liu Linsheng, Xenobiotica: the fate of foreign compounds in biological systems . 2019,第1a6期

机译：使用正电子发射断层扫描和药代动力学 - 药效模型预测大鼠大鼠罗比里奥洛唑的多巴胺D-2受体占用
4. Bioinformatics-inspired non-parametric modelling of pharmacokinetics-pharmacodynamics systems using differential neural networks [C] . Mariel Alfaro-Ponce, Isaac Chairez International Joint Conference on Neural Networks . 2020

机译：使用差分神经网络的生物信息学启发的药代动力学-药效学系统非参数建模
5. Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach. [D] . Chung, Eun Kyoung. 2015

机译：使用群体药代动力学/药效学方法，与非肥胖患者相比，肥胖患者的β-内酰胺抗菌药物剂量优化。
6. Neuroprotective Effect of Ropinirole Lipid Nanoparticles Enriched Hydrogel for Parkinson’s Disease: In Vitro Ex Vivo Pharmacokinetic and Pharmacodynamic Evaluation [O] . Narendar Dudhipala, Thirupathi Gorre 2020

机译：Ropinirole脂纳米粒子的神经保护作用富含水凝胶的帕金森病：体外离体药代动力学和药效学评估
7. Neuroprotective Effect of Ropinirole Lipid Nanoparticles Enriched Hydrogel for Parkinson’s Disease: In Vitro, Ex Vivo, Pharmacokinetic and Pharmacodynamic Evaluation [O] . Narendar Dudhipala, Thirupathi Gorre 2020

机译：Ropinirole脂纳米粒子的神经保护作用富含水凝胶的帕金森病：体外，离体，药代动力学和药效学评估

Pharmacokinetics and pharmacodynamics of ropinirole in patients with prolactinomas

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