Positive staining of the immunoligand B7-H6 in abnormal/transformed keratinocytes consistently accompanies the progression of cervical cancer

摘要

Representative immunohistochemical staining pattern of B7-H6 in cervical precancerous lesions and invasive cervical cancer. Specimens were categorized as follows: ( ) ovarian cystadenoma (as the positive control): B7-H6 is mainly expressed in lining epithelium; ( ) cervicitis: absence of B7-H6 in keratinocytes; ( ) LSIL: absence of B7-H6 in abnormal keratinocytes; ( ) HSIL: presence of B7-H6 in abnormal keratinocytes; ( ) SCC: B7-H6 expression in transformed tumoral cells; ( ) UCAC: strong expression of B7-H6 in transformed tumoral cells. Positive staining of B7-H6 is seen in the cytoplasm and membrane of transformed cells, and in plasma cells and mononuclear cells infiltrating the stroma. Photomicrographs were taken with different objectives (10x, 20x, and 40x).