首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Sensitivity and Specificity of Human Immunodeficiency Virus Rapid Serologic Assays and Testing Algorithms in an Antenatal Clinic in Abidjan Ivory Coast
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Sensitivity and Specificity of Human Immunodeficiency Virus Rapid Serologic Assays and Testing Algorithms in an Antenatal Clinic in Abidjan Ivory Coast

机译:象牙海岸阿比让产前诊所中人类免疫缺陷病毒快速血清学检测方法的敏感性和特异性

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摘要

To evaluate serologic testing algorithms for human immunodeficiency virus (HIV) based on a combination of rapid assays among persons with HIV-1 (non-B subtypes) infection, HIV-2 infection, and HIV-1–HIV-2 dual infections in Abidjan, Ivory Coast, a total of 1,216 sera with known HIV serologic status were used to evaluate the sensitivity and specificity of four rapid assays: Determine HIV-1/2, Capillus HIV-1/HIV-2, HIV-SPOT, and Genie II HIV-1/HIV-2. Two serum panels obtained from patients recently infected with HIV-1 subtypes B and non-B were also included. Based on sensitivity and specificity, three of the four rapid assays were evaluated prospectively in parallel (serum samples tested by two simultaneous rapid assays) and serial (serum samples tested by two consecutive rapid assays) testing algorithms. All assays were 100% sensitive, and specificities ranged from 99.4 to 100%. In the prospective evaluation, both the parallel and serial algorithms were 100% sensitive and specific. Our results suggest that rapid assays have high sensitivity and specificity and, when used in parallel or serial testing algorithms, yield results similar to those of enzyme-linked immunosorbent assay-based testing strategies. HIV serodiagnosis based on rapid assays may be a valuable alternative in implementing HIV prevention and surveillance programs in areas where sophisticated laboratories are difficult to establish.
机译:基于快速检测方法对阿比让HIV-1(非B亚型)感染,HIV-2感染和HIV-1-HIV-2双重感染者的血清学检测算法的评估,以评估人类免疫缺陷病毒(HIV)的血清学检测算法,象牙海岸,共有1,216份具有已知HIV血清学状况的血清用于评估四种快速检测的敏感性和特异性:确定HIV-1 / 2,Capillus HIV-1 / HIV-2,HIV-SPOT和Genie II HIV-1 / HIV-2。还包括从最近感染了HIV-1亚型B和非B的患者中获得的两个血清样本。基于敏感性和特异性,对四种快速测定法中的三种分别进行了平行(通过两个同时快速测定法检测血清样品)和串行(通过两个连续快速测定法检测血清样品)检测算法的评估。所有测定均为100%敏感,特异性范围为99.4至100%。在前瞻性评估中,并行和串行算法都是100%敏感和特定的。我们的结果表明,快速测定具有很高的灵敏度和特异性,当用于并行或串行测试算法时,产生的结果类似于基于酶联免疫吸附测定的测试策略。基于快速测定的艾滋病毒血清诊断可能是在难以建立复杂实验室的地区实施艾滋病预防和监测计划的有价值的替代方法。

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