N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice

摘要

Effect of oral NAC on infected mice on paw edema histological damage and neutrophil infiltration in paw skin. Paw edema ( ) was assessed at the time points indicated after subcutaneous injection of into the mice hind paw. NAC administration (200 mg/kg) produced significant improvements in this scores. Histological analysis was achieved by hematoxylin/eosin staining in sham; ( ), subcutaneously infected mice into the hind paw ( ), and subcutaneously infected mice + NAC (200 mg/kg) ( ); moreover myeloperoxidase (MPO) activity in paw skin was evaluated ( ). Figures are representative of at least three independent experiments for all animals from each group. Values are means ± SEM of five animals for each group.  L. amazonensis infected mice;