The secondary KIT mutation p.Ala510Val in a cutaneous mast cell tumour carrying the activating mutation p.Asn508Ile confers resistance to masitinib in dogs

摘要

Cutaneous mass HE × 200 Neoplastic round cells with numerous mitoses (arrows); ) Cutaneous mass Toluidine Blue × 400: numerous metachromatic granules in the cell cytoplasm; ) Renal biopsy: HEx200: Neoplastic round cells replacing the renal parenchyma (one residual tubule still visible); ) Renal biopsy: Toluidine Blue × 400: Regular inconspicuous metachromatic granulations (arrows)