pSpatiocyte: a high-performance simulator for intracellular reaction-diffusion systems

摘要

Intracellular space plays an important role in many biochemical systems operating in the timescales of minutes to hours such as cell signaling [ ], division [ ], polarization [ ], morphogenesis [ ] and chemotaxis [ , ]. These systems are regulated by the spatiotemporal dynamics of molecules. Recent quantitative biology methods can obtain high-resolution spatiotemporal measurements of the molecules. These disparate sources of measurements can be combined and interpreted using spatially resolved simulators to construct models of the systems that are realistic and consistent with physical principles. By simulating the models, detailed analysis of the systems can be conducted in silico and future experiments can be designed [ ].