Multidomain protein structure prediction using information about residues interacting on multimeric protein interfaces

摘要

Protein functions can be predicted based on their three-dimensional structures. However, many multidomain proteins have unstable structures, making it to determine the whole structure in biological experiments. Additionally, multidomain proteins are with the structure of each domain often found in public databases. Recent studies have advanced structure prediction methods of multidomain proteins through computational analysis. In existing methods, proteins that serve as templates are used for three-dimensional structure prediction. However, when no protein template is available, the accuracy of the prediction is decreased. This study was conducted to predict the structures of multidomain proteins without the need for whole structure templates.