Quantification of Nicotine and Cotinine in Plasma Saliva and Urine by HPLC Method in Chewing Tobacco Users

摘要

Nicotine acts as major alkaloid of all tobacco products including smokeless tobacco (SLT) forms. The mode of SLT consumption is in the form of chewing under the cheek or lip and induced biochemical alterations in the plasma, saliva, and urine.