Prognostic Relevance of SFRP1 Gene Promoter Methylation in Colorectal Carcinoma

摘要

The development of colorectal carcinoma (CRC) involves many genetic and epigenetic alterations and methylation being an important epigenetic event has been described as a diagnostic and prognostic biomarker. Secreted Frizzled- Related Protein 1 ( ) gene regulates diverse physiological processes via the Wnt signaling. Promoter hypermethylation of gene is an epigenetic regulation mechanism that downregulates protein level in the tumor, and happens to be one of the significant events in colorectal carcinogenesis. We studied the clinicopathological relationship of CRC including survival outcomes with gene promoter methylation.