Brain tumor with an ATXN1-NUTM1 fusion gene expands the histologic spectrum of NUTM1-rearranged neoplasia

摘要

gene fusion, confirmed by RT-PCR and Sanger sequencing ( ). MRI identified a frontal mass. Enhancement after contrast injection (T1) ( ). Representative histopathology. On the left, loose area with neuron-like tumor cells (*detail). On the right, increase in cell density ( ). Fascicular architecture with three mitoses (arrows) ( ). Chondroid-like, myxoid and hyalinized areas were observed ( ). Undifferentiated cells with large nucleoli in a chondromyxoid background ( ). Strong GFAP staining was observed. Tumor showed vascular proliferation ( ). Neurofilament staining circumscribed the tumor mass with no significant staining within the tumor ( ). p53 accumulated in tumor nuclei ( ). Anti-NUT antibody staining showing homogeneous intranuclear expression ( )