Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

摘要

Behavioral characterization of HMBS-deficient mice. 24 h mobility patterns in male and female HMBS-deficient (KI) and wildtype (WT) control mice. Assessment of depression-like behavior in SPT (% sucrose preference), NSF (latency until first bite) without alterations in body weight loss during food deprivation. Behavioral despair in the TST (% of time spent immobile). Examination of anxiety-like behavior in LD (% of time in light compartment) and EPM (% of entries into open arms). All values are presented as mean ± SEM;  = 6–19 per group. Statistical significances displayed refer to genotype effects (*) and sex effects (∆) resulting from repeated measure and 2-way ANOVA. *  p p