Chemical Transformation of Prostaglandin-A2: A Novel Series of C-10 Halogenated C-12 Hydroxylated Prostaglandin-A2 Analogues

摘要

Synthesis of a novel class of C-10 halogenated and C-12 oxygenated prostaglandin-A2 derivatives 6(a–c) has been accomplished. (15S)-Prostaglandin-A2 (1), from the gorgonian Plexaura homomalla, served as the starting material for the synthesis. The absolute configuration was determined using NMR.