Total Synthesis of (−)-Normalindine via Addition of Metallated 4-Methyl-3-cyanopyridine to an Enantiopure Sulfinimine

摘要

A concise total asymmetric synthesis of the tetrahydronaphthridine alkaloid (−)-normalindine has been accomplished via the addition of a laterally metallated 4-methyl-3-cyanopyridine to a sulfinimine (N-sulfinyl imine) as the key step.