Clinical Significance of Serum Angiocidin Levels in Hepatocellular Carcinoma

摘要

Angiocidin, a tumor-secreted protein, was measured in serum of 27 healthy volunteers and 33 hepatocellular carcinoma (HCC) patients. Healthy controls either hepatitis B surface antigen (HBsAg) positive or negative showed undetectable levels. Patients had levels of angiocidin ranging from 15.09–195.73 pg/ml. Patients with stages III–IV had higher levels of angiocidin (97±13 pg/ml, n=17) compared to those with stages I–II (63±37 pg/ml, n=16), p<0.043. Patients with microsatellite tumor nodules had higher average levels (98±55 pg/ml, n=17) compared to those without microsatellite nodules (51± 27 pg/ml, n=20), p<0.032. Our studies suggest that angiocidin predicts advanced stage and intra-hepatic metastasis.