Impaired Cognitive Flexibility and Motor Inhibition in Unaffected First-Degree Relatives of Patients with Obsessive-Compulsive Disorder

摘要

Objective:Obsessive-compulsive disorder (OCD) is highly heritable. Attempts to delineate precise genetic contributions have met with limited success. There is an ongoing search for intermediate cognitive brain markers (endophenotypes) that may help clarify genetic contributions. The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with objective tests.