Callophycoic Acids and Callophycols from the Fijian Red Alga Callophycus serratus

摘要

Callophycoic acids A–H (>1–>8) and callophycols A and B (>9 and >10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene–benzoic acids and diterpene–phenols in macroalgae. Compounds >1–>10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.