Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus

摘要

ObjectiveHypotonic solutions cause vasoconstriction in rat tail arteries, due largely to activation of L-type calcium channels (CaV1.2). We studied possible roles of tyrosine kinases, particularly src family kinases (SFK) and extracellular signal-related kinases (ERK1/2), in this response.