The binding and buffering of O2 and CO2 in the blood influence their exchange in lung and tissues and their transport through the circulation. To investigate the binding and buffering effects, a model of blood-tissue gas exchange is used. The model accounts for hemoglobin saturation, the simultaneous binding of o2 CO2. H+, 2,3-DPG to hemoglobin, and temperature effects [,]. Invertible Hill-type saturation equations facilitate rapid calculation of respiratory gas redistribution among the plasma, red blood cell and issue that occur along the concentration gradients in the lung and in the capillary-tissue exchange regions. These equations are well-suited to analysis of transients in tissue metabolism and partial pressures of inhaled gas. The modeling illustrates that because red blood cell velocities in the flowing blood are higher than plasma velocities after a transient there can be prolonged differences between RBC and plasma oxygen partial pressures. The blood-tissue gas exchange model has been incorporated into a higher level model of the circulatory system plus pulmonary mechanics and gas exchange using the RBC and plasma equations to account for pH and CO2 buffering in the blood.
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机译:血液中O2和CO2的结合和缓冲影响它们在肺和组织中的交换以及它们在循环系统中的运输。为了研究结合和缓冲作用,使用了血液-组织气体交换模型。该模型解释了血红蛋白饱和度,o2 CO2的同时结合。 H + sup>,2,3-DPG对血红蛋白的影响和温度效应[,]。可逆的希尔式饱和度方程有助于快速计算血浆,红细胞和呼吸气体在肺和毛细血管组织交换区域中沿浓度梯度发生的再分布。这些方程式非常适合分析组织代谢的瞬态变化和吸入气体的分压。该模型说明,由于瞬变后流动的血液中的红细胞速度高于血浆速度,因此RBC和血浆氧分压之间的差异可能会延长。使用RBC和血浆方程式将血液组织气体交换模型纳入循环系统的高级模型以及肺部力学和气体交换,以解决血液中的pH和CO2缓冲问题。
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