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Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue U46619

机译：一氧化氮和伊洛前列素在血栓烷A2类似物U46619响应中对一氧化氮和伊洛前列素对一氧化氮和Rac1活化的急性抑制作用

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摘要

BackgroundThe over-production of superoxide (

O_{2}^{\cdot -}

) derived from NADPH oxidase (NOX) plays a central role in cardiovascular diseases. By contrast, nitric oxide (NO) and prostacyclin (PGI2) are vasculoprotective. The effect of the NO donor, NONOate and iloprost on

O_{2}^{\cdot -}

formation, p47^phox and Rac1 activation in human vascular smooth muscle cells (hVSMCs) was investigated.

机译：背景超氧化物的过量生产（ < msubsup> O 2 ⋅ − 源自NADPH氧化酶（NOX）的）在心血管疾病中起着重要作用。相比之下，一氧化氮（NO）和前列环素（PGI2）具有血管保护作用。 NO施主，NONOate和iloprost对

O2\cdot-研究了人血管平滑肌细胞（hVSMC）中的形成，p47phox 和Rac1的活化。

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期刊名称 other
作者
S. Muzaffar; N. Shukla; M. Bond; G. Sala-Newby; G.D. Angelini; A.C. Newby; J.Y. Jeremy;
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年(卷),期 -1(78),4-5
年度 -1
页码 247–255
总页数 15
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专利

1. Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619. [J] . Muzaffar S, Shukla N, Bond M, Prostaglandins, Leukotrienes, and Essential Fatty Acids . 2008 ,第4a5期

机译：一氧化氮和伊洛前列素对血栓烷A2类似物U46619的反应，通过一氧化氮和伊洛前列素对超氧化物形成和Rac1活化的急性抑制作用。
2. Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD(P)H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. [J] . Koupparis AJ, Jeremy JY, Muzaffar S, BJU international . 2005 ,第3期

机译：西地那非可抑制海绵体平滑肌细胞中血栓素A2模拟物U46619诱导的超氧化物的形成和gp47 NAD（P）H氧化酶的表达。
3. NADPH oxidase 1 mediates upregulation of thromboxane A2 synthase in human vascular smooth muscle cells: inhibition with iloprost. [J] . Muzaffar S, Shukla N, Massey Y, European Journal of Pharmacology: An International Journal . 2011 ,第2a3期

机译：NADPH氧化酶1介导人血管平滑肌细胞中血栓烷A2合酶的上调：伊洛前列素的抑制作用。
4. Thrombin-induced HB-EGF expression in human arterial and venous vascular smooth muscle cells: characterization of signaling pathways and regulation by iloprost [C] . R. Pape, K. Schro Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

机译：凝血酶诱导的HB-EGF在人类动脉和静脉血管平滑肌细胞中表达：信号传导途径和ILOPROST调节的表征
5. Signaling mechanism by which thromboxane receptor activation modulates interleukin-1[beta]-induced monocyte adhesion and nuclear factor [kappa]B-dependent gene expression in vascular smooth muscle cells [D] . Bayat, Hossein 2008

机译：血栓烷受体激活调节血管平滑肌细胞中白介素-1β诱导的单核细胞粘附和核因子κB依赖性基因表达的信号传导机制
6. Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate [O] . S Muzaffar, N Shukla, M Bond, 2008

机译：NADPH氧化酶中的超氧化物上调人血管平滑肌细胞中的5型磷酸二酯酶：伊洛前列素和NONOate的抑制作用
7. Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619 [O] . S. Muzaffar, N. Shukla, M. Bond, 2008

机译：用血管平滑肌细胞在人血管平滑肌细胞中急性抑制超氧化物形成和RAC1活化，响应血栓X2类似物，U46619

Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue U46619

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